BASIC SCIENTIFIC RESEARCHROBERT E. BURKE(The Burke Laboratory website) Studies of mechanisms of programmed cell death in models of neurodegeneration related to disorders of the basal ganglia, especially parkinsonism. Studies are conducted both in vivo and in vitro, utilizing immunohistochemistry, quantitative morphologic analysis, in situ hybridization, differential display, receptor autoradiography, and enzyme assays. SERGE PRZEDBORSKI(Neuroscience Research Laboratory Website) Study of toxin-induced damage to neurotransmitter systems pertinent to movement disorders such as Parkinson disease, amyotrophic lateral sclerosis and Huntington disease. Modes of cell death and free radical-induced toxicity are also investigated. SOD1 mutant transgenic mice serve as a model for amyotrophic lateral sclerosis. Methods include transgenic mice, immunohistochemistry, in situ hybridization, quantitative morphology, receptor binding, HPLC, and classical histology. DAVID SULZER(Sulzer Laboratory Website) Study of dopamine synaptic plasticity and its pharmacological manipulation by drugs used for treatment of Parkinson disease and schizophrenia, as well as modulation by intrinsic synaptic proteins. Investigations also include mechanisms of addictive drugs associated with dopamine systems and cell culture models of catecholamine neurotoxicity and neurodegeneration. Methods include electrophysiology, electrochemistry, HPLC, quantitative microscopy, molecular biology, and neuronal cell culture. |
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