At the Center for Parkinson's Disease and Other Movement Disorders, researchers have conducted investigations into the causes of movement disorders, including Parkinson's disease and related disorders, dystonia, myoclonus, tremor. Clinician-researchers have tested and developed new therapeutic approaches to the treatment of movement disorders. Whether basic science or clinical, most of the research is driven by questions pertaining to specific diseases in patients. The research is published in peer-reviewed journals. In the sections that follow, the research accomplishments of this Division of the Department of Neurology are described, with an accompanying bibliography of published work.
Basic Science Research
The investigators in the basic science research laboratories of the Center have investigated the causes of cell death in Parkinson's disease and experimental therapies that may yield future clinical treatments. The work includes research in trophic factors, programmed cell death, oxidative stress, and neurotoxins affecting dopamine neurons. Investigators in the molecular genetics laboratories have made important discoveries in Parkinson's disease and dystonia. For detailed information regarding current basic science or "bench" research, see FACULTY, then click on the each research faculty name.
In its clinical research, the Center has carried out many clinical trials of therapeutic agents in movement disorders, motor control, observation and family studies. All of the drugs currently used for the treatment of Parkinson's disease were originally experimental therapeutic trials in which members of the Center participated. The Center has also pioneered investigations on all the therapies currently available for dystonia. More recent or ongoing clinical research includes the newer medications for Parkinson's disease, human fetal tissue transplantation, neuroprotective trials for Parkinson's disease, essential tremor, musicians' dystonia and innovative surgical treatments for Parkinson's disease.
Clinical genetics has been a major focus of the Center. Important work leading to the identification of the genes for dystonia, dopa-responsive dystonia (DRD), X-linked dystonia-parkinsonism (Lubag), and fronto-temporal dementia was conducted here. Ongoing research is devoted to hereditary essential myoclonus, essential tremor, and the genetics of Parkinson's disease.
For more information, see Clinical Research Studies
Funding for our research comes from the National Institutes of Health, the Parkinson's Disease Foundation, the Leon Lowenstein Foundation, the Myoclonus Research Foundation, the Helis Foundation, and from many of our patients.
DONATIONS OF SUPPORT
Private donations support today's research efforts to learn more about each movement disorder. A gift to the Center for Parkinson's Disease and Other Movement Disorders at Columbia University will bring us all closer to our shared goal: more effective treatments and preventive therapies. As a supporter of our Center, you join other generous individuals and families in contributing to a better world. Memorial gifts are a living tribute to a friend or loved one who had a movement disorder. Many bereaved families encourage memorial contributions toward our research—instead of flowers.
Planned giving options that are tailored to your financial and charitable goals may be discussed in detail with Columbia University's Health Sciences Development Office, whether you are giving securities, bequests, life income annuities, trusts or other tax-advantageous gifts.
Donations may be checks made payable to Columbia University sent to the attention of Dr. Stanley Fahn, Director, Center for Parkinson's Disease and Other Movement Disorders, 710 West 168 Street, New York, NY 10032
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Copyright © 2004 The Neurological Institute of New York || Columbia University Medical Center Center for Parkinson Disease & Other Movement Disorders
Affiliated with New York-Presbyterian Hospital
710 W 168th St, New York, NY 10032
March 30, 2012